Headway on Migraine Headaches

Headway Episode #12: Migraine as a Progressive Disorder

Interview with: Stephen D. Silberstein, MD, FACP

Disclosure: Dr. Silberstein has received grants from Abbott, Advanced Bionics, Advanced Neuro-Modulation System, AGA, Lilly, ProEthic and Vernalis. He has received grants and honorarium from Allergan, AstraZeneca, Endo Pharmaceuticals, GlaxoSmithKline, Medtronic, Merck, Ortho-McNeil, Pfizer, Pozen and Valeant Pharmaceuticals.

News Topper References:
1. Rodés-Cabau J, Mineau S, Marrero A, et al. Incidence, timing and predictive factors of new-onset migraine headache occurrence after transcatheter closure of atrial septal defects or patent foramen ovale. Abstract presented at: European Society of Cardiology Annual Congress; Sept 1-5, 2007; Vienna, Austria. Abstract #4258.

2. Marrero A, Rodés-Cabau J, Mineau S, Marrero, et al. Incidence, timing and predictive factors of new-onset migraine headache occurrence after transcatheter closure of atrial septal defects or patent foramen ovale. Slides presented at: European Society of Cardiology Annual Congress; Sept 1-5, 2007; Vienna, Austria; Slides available at: http://spo.escardio.org/eslides/presenter.aspx?eevtid=19&letter=M. Accessed December 11, 2007.

3. Jancin, B. Cardiac procedure linked to new-onset migraine. Clinical Neurology News. 2007;3(10):1, 6.

4. Beda RD, Gill EA Jr. Patent foramen ovale: Does it play a role in the pathophysiology of migraine headache? Cardiol Clin. 2005;23:91–96.

5. Giardini A, Donti A, Formigari R, et al. Transcatheter patent foramen ovale closure mitigates aura migraine headaches abolishing spontaneous right-to-left shunting. Am Heart J. 2006;922:e1-922.e5.

6. Slavin L, Tobis JM, Rangarajan K, Dao C, Krivokapich J, Liebeskind DS. Five-year experience with percutaneous closure of patent foramen ovale. Am J Cardiol. 2007;99:1316-1320.

7. Valente AM, Rhodes JF. Current indications and contraindications for transcatheter atrial septal defect and patent foramen ovale device closure. Am Heart J. 2007;153(4 Suppl):81-84.

Interview References:
1. Loder E, Biondi D. Disease modification in migraine: A concept that has come of age? Headache. 2003;43:135-143.

2. Bigal, ME, Rapoport AM, Sheftell FD, Tepper SJ, Lipton RB. Chronic migraine is an earlier stage of transformed migraine in adults. Neurology. 2005;65:1556-1561.

3. Lipton RB, Pan J. Is migraine a progressive brain disease? JAMA. 2004;291:493-494.

4. Schreiber CP. The pathophysiology of migraine. Clin Fam Pract. 2005;7:407-421.

5. Silberstein SD, Lipton RB, Ramadan NM. From migraine mechanisms to innovative
therapeutic drugs. Neurology. 2005;64(suppl 2):S1-S3.

6. Burstein R, Yarnitsky D, Goor-Aryeh I, et al. An association between migraine and
cutaneous allodynia. Ann Neurol. 2000;47:614–24.

7. Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race
against the development of cutaneous allodynia. Ann Neurol. 2004;55:19–26.

8. Smith TR. The pharmacologic treatment of the acute migraine attack. Clin Fam Pract. 2005;7:423-444.

9. Bousser M-G, Welch MA. Relation between migraine and stroke. Lancet Neurol. 2005; 4:533–542.

10. Milhaud D, Bogousslavsky J, van Melle G, Liot P. Ischemic stroke and active migraine. Neurology. 2001;57:1805-1811.

11. Bushnell CD. Oestrogen and stroke in women: Assessment of risk. Lancet Neurol. 2005;4:743–751.

12. Kurth T, Slomke MA, Kase CS, et al. Migraine, headache, and the risk of
stroke in women: A prospective study. Neurology. 2005;64:1020–1026.

13. Etminan M, Takkouche B, Isorna FC, Samii A. Risk of ischaemic stroke in people with migraine: Systematic review and meta-analysis of observational studies. BMJ. 2005;330: 63.

14. Armstrong C. ACOG releases guidelines on hormonal contraceptives in women with coexisting medical conditions. Am Fam Physician. 2007;75;1252-1258.

15. Tepper SJ, Dahlof CGH, Dowson A, et al. Prevalence and diagnosis of migraine in patients consulting their physician with a complaint of headache: Data from the Landmark Study. Headache. 2004;44:856-864.

 

 Standard Podcast [17:57m]: Play Now | Play in Popup | Download

Publication date: January 28, 2008

Interview with: Richard B. Lipton, MD

Disclosure: Dr. Lipton has received grants from Advanced Bionics, Allergan, GlazoSmithKline, Minster, Merck, Neuralieve, OrthoMcNeil, Pfizer, ProEthics and St. Jude’s. He has been a consultant for Advanced Bionics, Allergan, Boehringer-Ingelheim, Bristol Myers Squibb, Cierra, Endo, Neuralieve, Novartis, OrthoMcNeil, Pfizer, Pozen and ProEthics. Dr. Lipton has also received honoraria from Allergan, AstraZeneca, GlaxoSmithKline, Minster, Merck, Neuralieve, Novartis, OrthoMcNeil and Pfizer.

News Topper References:

1. Dahlof C, Johansson M, Mellberg A. Does the pattern of migraine change over time? A 12-year perspective. Headache. 2007;47:741-812.

2. Sullivan MG. One-third of migraineurs can expect complete pain cessation. Clinical Neurology News. 2007;3(September):17.
Interview References:

1. Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF, on behalf of the AMPP Advisory Group. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68:343–349.

2. Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. J Am Med Assoc. 1992;267:64–69.

3. Lipton RB, Diamond S, Reed ML, Diamond ML, Stewart WF. Migraine diagnosis and treatment: Results from the American Migraine Study II. Headache. 2001;41:638–645.

4. Prevalence of chronic migraine headaches—United States, 1980-1989. MMWR Morb Mortal Wkly Rep. 1991;40:331, 337–338.

5. Sadovsky R, Dodick DW. Identifying migraine in primary care setting. Am J Med. 2005;118 (suppl 1):11S-17S.

6. Diamond S, Bigal ME, Silberstein S, Loder E, Reed M, Lipton RB. Patterns of diagnosis and acute and preventive treatment for migraine in the United States: Results from the American Migraine Prevalence and Prevention Study. Headache. 2007;47:355-363.

7. Bigal ME, Lipton RB. Modifiable risk factors for migraine progression. Headache. 2006;46:1334-43.

8. The International Classification of Headache Disorders revised criteria for chronic migraine-field testing in a headache specialty clinic. Cephalalgia. 2007;29:11, 31.

 

 #11: American Migraine Prevalence and Prevention Study [24:44m]: Play Now | Play in Popup | Download

Publication date: November 28, 2007

Interview with: Dr. Vincent T. Martin, MD

Disclosure: Dr. Martin has received clinical grants from, and has been a consultant and speaker for, GlaxoSmithKline.

News Topper References:

1. Wachter K. Combination treatment reduced migraine activity. Clinical Neurology News 2007;3;8:10.
2. Holroyd K et al. Neither Preventative medication nor behavioral migraine management improve optimal acute therapy outcomes, but their combination does: The Treatment of Severe Migraine (TSM) trial, P803.   Journal of Pain 2007; 8;4: Suppl1.

Interview References:

1. Peters KS. Secondary headache and head pain emergencies.  Primary Care: Clinics in Office Practice. 2004; 31: 381-93
2. Bigal M, Bordini CA, Speciali JG. Etiology and distribution of headaches in two Brazilian primary care units. Headache 2000; 40: 241-47
3. Loh NK, Dinner DS, Foldvary N, Skobieranda F, Yew WW. Do patients with obstructive sleep apnea wake up with headaches.  Arch Int Med 1999; 159: 1765-8  (can’t highlight article/p 1766)
4. Friedman DI. Idiopathic intracranial hypertension.  Current Pain and Headache Reports 2007; 11: 62-8.
5. Bousser M. Kittner SJ. Oral contraceptives and stroke. Cephalalgia 2000; 20: 183-89
6. Cantu C, Barinagarrementeria F. Cerebral venous thrombosis associated with pregnancy and puerperium. Review of 67 cases.  Stroke 1993; 24: 1880-84.
7. Smetana GW Shmerling RH. Does this patient have temporal arteritis. JAMA 2002: 287: 92-101 (can’t highlight p92)
8. Ward T, Levin M, Phillips JM. Evaluation and management of Headache in the Emergency Department. Med Clin N America 2001; 85: 971-985
9. Kaniecki R. Headache Assessment and Management. JAMA 2003; 289: 1430-1433. Martin, V. Simplifying the Diagnosis of Migraine Headache. Advanced Studies in Medicine 2004; 4 (4): 200-207.
10. Dodick D. Thunderclap headache. J Neurol Neurosurg Psych 2002;72: 6-11
11. Martin, V. Simplifying the Diagnosis of Migraine Headache. Advanced Studies in  Medicine 2004; 4 (4): 200-207. (can’t highlight pgs 201, 202, 205)
12. Medina LS, D’Souza B, Vasconcellos E. Adults and children with headache: evidence-based diagnostic evaluation. Neuroimaging Clin N America 2003; 13: 225-35
13. Evans R. Diagnostic testing for headache. Med Clin N Am.  2001; 85; 865-885.
14. Van der Wee N., Rinkel, GJ, Hasan D, van Gijn J.  Detection of subarachnoid haemorrhage on early CT: is lumbar puncture still needed after a negative scan?  J Neurol Neurosurgery Psychiatry 58: 357-79, 1995.
15. Demopoulos A. Leptomeningeal Metastases. Curr Neurol Neurosci Rep 2004; 3: 196-204

 

 #10: Headache Assessment: Ruling Out Secondary Causes [18:14m]: Play Now | Play in Popup | Download

Publication date: November 19, 2007

Interview with: Paul Winner, DO, FAAN

Disclosure: Dr. Winner has received clinical grants from, and has been a consultant for, GlaxoSmithKline.

News Topper References:

1. Migraine With Psychiatric Disorder Associated with Resource Use, Poorer Health, Canadian Researcher Says, Elsevier Global Medical News, posted June 11, 2007 12:46PM EDT.
2. © 2007 Elsevier Global Medical News.
3. Lipton RB, Bigal ME. The epidemiology of migraine. Am J Med. 2005;118(Suppl 1):3S-10S.
4. Brandt J, Celentano D, Stewart W, Linet M, Folstein MF. Personality and emotional disorder in a community sample of migraine headache sufferers. Am J Psychiatry. 1990;147:303-308.
5. Merikangas KR, Angst J, Isler H. Migraine and psychopathology. Results of the Zurich cohort study of young adults. Arch Gen Psychiatry. 1990;47:849-853.
6. Molgat CV, Patten SB. Comorbidity of major depression and migraine—a Canadian population-based study. Can J Psychiatry. 2005;50:832-837.
7. Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. JAMA. 1992;267:64-69.
8. Swartz KL, Pratt LA, Armenian HK, Lee LC, Eaton WW. Mental disorders and the incidence of migraine headaches in a community sample: results from the Baltimore Epidemiologic Catchment area follow-up study. Arch Gen Psychiatry. 2000;57:945-950.

Interview References:

1. International Classification of Headache Disorders. 2nd edition. Cephalalgia. 2004;24:1-160.
2. Sadovsky R, Dodick D. Identifying migraine in primary care settings. Am J Med. 2005;118(suppl 1):11S-17S.
3. Lipton RB, Stewart WF. Acute migraine therapy: Do doctors understand what patients with migraine want from therapy? Headache. 1999;39(suppl 2):S20-S26.
4. Bigal M, Rapoport A, Aurora S, Sheftell F, Tepper S, Dahlof C. Satisfaction with current migraine therapy: Experience from 3 centers in US and Sweden. Headache. 2007;47:475-479.
5. Mathew NT, Loder EW. Evaluating the triptans. Am J Med. 2005;118(suppl 1):28S-35S.
6. Imitrex (sumatriptan succinate) Prescribing Information. GlaxoSmithKline, Research Triangle Park, N.C.
7. Zomig (zolmitriptan) Prescribing Information. AstraZeneca Pharmaceuticals, Wilmington, Del.

 

 #9: Managing Migraines in Young Adults [18:47m]: Play Now | Play in Popup | Download

Publication date: September 19, 2007

Interview with: KMA Welch, MB, ChB, FRCP

 

 #8: Multiple Mechanisms of Migraine [21:51m]: Play Now | Play in Popup | Download

Disclosure: Dr. Welch has received clinical grants from NIH Research supported by NINDS. He has also been a lecturer and on the advisory board for GlaxoSmithKline. He has also been on the advisory board for Ortho McNeill and has been a lecturer and part of the advisory board and steering committee for Pfizer.

News Topper References

Occipital Nerve Stimulation Effective for Some Headaches, Clinical Neurology News, August 2007, Elsevier Inc.

1. Magis D, Allena M, Bolla M, De Pasqua V, Remacle J-M, Schoenen J. Occipital nerve stimulation for drug-resistant chronic cluster headache: A prospective pilot study. Lancet Neurol. 2007;6:314-321.
2. Burns B, Watkins L, Goadsby PJ. Treatment of medically intractable cluster headache by occipital nerve stimulation: Long-term follow-up of eight patients. Lancet. 2007;369:1099-1106..
3. Schwedt TJ, Dodick DW, Trentman TL, Zimmerman RS. Response to occipital nerve block is not useful in predicting efficacy of occipital nerve stimulation. Cephalalgia. 2007;27:271-274.

Interview References

1. Bolay M, Reuter U, Dunn A, Huang Z, Boas D, Moskowitz M. Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nature Med. 2002;8:136-142.
2. Van den Maagdenberg A, Pietrobon D, Pizzorusso T, et al. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004;41:701-710.
3. Ophoff RA, Terwindt GM, Vergouwe MN, et al. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca2+ channel gene CACNL1A4. Cell. 1996;87:543-552.
4. DeFusco M, Marconi R, Silvestri L, et al. Haploinsufficiency of ATP1A2 encoding the Na+/K+ pump alpha2 subunit associated with familial hemiplegic migraine type 2. Nature Genetics. 2003;33:192-196.
5. Dichgans M, Freilinger T, Eckstein G, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet. 2005;366:371-377.
6. Moskowitz MA. The neurobiology of vascular head pain. Ann Neurol. 1984;15:157-168.
7. Burstein R, Yarnitsky D, Goor-Aryeh T, Ransil BJ, Bajwa ZII. An association between migraine and cutaneous allodynia. Ann Neurol. 2000;47:614-624.

‘

8. Burstein R, Jakubowski M. Analgesic triptan action in an animal model of intracranial pain: A race against the development of central sensitization. Ann Neurol. 2004;55:27-36.

Publication date: July 31, 2007

Interview with: Stewart J. Tepper, MD

 

 #7: Patient Dissatisfaction with Current Migraine Therapies [21:22m]: Play Now | Play in Popup | Download

News Topper:

Scale Measures Migraine’s Effects on Quality of Life Between Attacks, Clinical Neurology News. 2007. Vol 3;5:16

Buse D et al. Development and Validation of the Migraine Interictal Burden Scale (MIBS): A Self-Administered Instrument for Measuring the Burden of Migraine Between Attacks. Neurology; 2007; 68; (Suppl 1), pA89.

Lipton RB, Stewart WF, Sawyer J, Edmeads JG. Clinical utility of an instrument assessing migraine disability: the Migraine Disability Assessment (MIDAS) questionnaire. Headache. 2001;41:854-861.

Interview:

1. Lipton RB, Diamond S, Reed M, Diamond ML, Stewart WF. Migraine diagnosis and treatment: results from the American Migraine Study II. Headache. 2001;41:638-645.
2. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia. 1988;8 (Suppl 7):1-96.
3. Bigal M, Rapoport A, Aurora S, Sheftell F, Tepper S, Dahlof C. Satisfaction with current migraine therapy: Experience from 3 Centers in US and Sweden. Headache. 2007;47:475-479.
4. Dowson AJ, Tepper SJ, Baos V, Baudet F, D’Amico D, Kilminster S. Identifying patients who require a change in their current acute migraine treatment: The Migraine Assessment of Current Therapy (Migraine-ACT) Questionnaire. 2004. Curr Med Res Opin. 20:1125-1135.
5. Kilminster SG, Dowson AJ, Tepper SJ, Baos V, Baudet F, D’Amico D. Reliability, validity, and clinical utility of the Migraine-ACT Questionnaire. Headache 2006;46:553-562.

Headway Episode #6: Cluster Headaches: Diagnostic Criteria and Treatment.

Interview with: Peter J. Goadsby, MD, PhD

Disclosure: Dr. Goadsby has nothing to disclose.

 

 #6: Cluster Headaches: Diagnostic Criteria and Treatment [18:08m]: Play Now | Play in Popup | Download

News Topper“Computerized Assessment Shows Balance Dysfunction in Migraine”, Clinical Neurology News, copyright Elsevier, 2007: 3;5: XX

Akdal G, Donmez B, Ozturk V, Angin S. Balance in Migraineurs. Neurology. 2007;68(Suppl 1): A89, presented at American Academy of Neurology, May 1, 2007 S05.004.]

Tobias Kurth - Migraine and the Risk of Hemorrhagic Stroke in Women presented at the International Stroke Conference 2007. Stroke 2007;38:458 abstract #22

Interview

1. Bahra A, May A, Goadsby PJ. Cluster headache: A prospective clinical study in 230 patients with diagnostic implications. Neurology. 2002;58:354-361.
2. Headache Classification Committee of The International Headache Society. The International Classification of Headache Disorders (second edition). Cephalalgia. 2004;24(Suppl 1):44-48.
3. Sjaastad O, Bakketeig LS. Cluster headache prevalence. Vaga study of headache epidemiology. Cephalalgia. 2003;23:528-533.
4. Bahra A, Goadsby PJ. Diagnostic delays and mis-management in cluster headache. Acta Neurologica Scandinavica. 2004;109:175-179.
5. Goadsby PJ. Pathophysiology of cluster headache: A trigeminal autonomic cephalgia. Lancet Neurol. 2002;1:37-43.
6. Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache. Brain. 1994;117:427-434.
7. May A, Goadsby PJ. The trigeminovascular system in humans: Pathophysiological implications for primary headache syndromes of the neural influences on the cerebral circulation. J Cerebral Blood Flow Metab. 1999;19:115-127.
8. Goadsby PJ, Cohen AS, Matharu MS. Trigeminal autonomic cephalalgias - diagnosis and treatment. Curr Neurol Neurosci Rep. 2007;7:117-125.
9. Mathew NT, Hurt W. Percutaneous radiofrequency trigeminal gangliorhizolysis in intractable cluster headache. Headache. 1988;28:328-331.
10. Jarrar RG, Black DF, Dodick DW, Davis DH. Outcome of trigeminal nerve section in the treatment of chronic cluster headache. Neurology. 2003;60:1360-1362.
11. Burns B, Watkins L, Goadsby PJ. Successful treatment of medically intractable cluster headache using occipital nerve stimulation (ONS). Lancet. 2007;369:1099-1106.
12. Magis D, Allena M, Bolla M, De Pasqua V, Remacle JM, Schoenen J. Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol. 2007;6:314-321.
13. Leone M. Deep brain stimulation in headache. Lancet Neurol. 2006;5:873-877.

Publication Date: June 2, 2007.

 

 #5: Menstrual Migraine with Dr. Lisa Mannix, M.D. [17:25m]: Play Now | Play in Popup | Download

Interview with: Robert G. Kaniecki, M.D.

Publication Date: May 4, 2007.

Disclosure: Dr. Kaniecki has been a speaker and consultant to GlaxoSmithKline.

 

 #4: Is It Tension Headache or Is It Migraine? [21:06m]: Play Now | Play in Popup | Download

Listen to the podcast.

News Topper

Worcester S. “Migraine with Aura may Independently Increase Stroke Risk,”, Clin Neuro News, Vol 3 No 3, Elsevier Inc. 2007.

Interview

1. Lipton RB, Stewart WF, Reed M, et al. Migraine’s impact today: Burden of illness, patterns of care. Postgrad Med. 2001;109:38-45.
2. Schreiber CP. The pathophysiology of migraine. Dis Mon. 2006;52:385-401.
3. Schreiber CP, Hutchinson S, Webster CJ, Ames M, Richardson MS, Powers C. Prevalence of migraine in patients with a history of self-reported or physician-diagnosed “sinus” headache. Arch Intern Med. 2004;164:1769-1772.
4. Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M. Prevalence and burden of migraine in the United States: Data from the American Migraine Study II. Headache. 2001;41:638-645.
5. Tepper SJ, Dahlof CG, Dowson A, et al. Prevalence and diagnosis of migraine in patients consulting their physician with a complaint of headache: Data from the Landmark Study. Headache. 2004;44:856-864.
6. Blumenthal HJ, Weisz MA, Kelly KM, Mayer RL, Blonsky J. Treatment of primary headache in the emergency department. Headache. 2003;43:1026-1031.

Publication Date: March 23, 2007.

 

 #3: Is it Migraine or Sinus Headache? Making the Diagnosis [17:29m]: Play Now | Play in Popup | Download

1. Eross EJ, Dodick DW, Eross MD. The Sinus, Allergy and Migraine Study (SAMS) [abstract]. Headache. 2004;44:462.[DISCUSSED IN: Cady RK, Dodick DW, Levine HL, et al. Headache: A neurology, otolaryngology, allergy, and primary care consensus on diagnosis and treatment. Mayo Clin Proc. 2005;80:908-916.]
2. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders. 2nd edition. Cephalalgia. 2004;24(suppl 1):117-118.
3. Schreiber CP. Prevalence of migraine in patients with a history of self-reported or physician-diagnosed “sinus” headache. Arch Intern Med. 2004;164:1769-1772.